New Techniques In IVF – Endometrial Receptivity Test



There are several instances when IVF fails, even when the embryo might be good. It is not uncommon to see patients who have undergone 3, 5 or even 8 cycles of IVF/ICSI.

In such circumstances, it is very important to evaluate to find out the reason. Of course, the quality of egg/sperm is important and if those are bad, the only option is to go for donor egg or donor sperm accordingly.
In case gamates and embryo are good, the reason could be failure of implantation. Implantation is the process by which communication happens between the embryo and the inner lining of the uterus. It happens through some chemicals which results in adherence of embryo and subsequent growth in the lining.
 Endometrial Receptivity Test, now introduced in India can diagnose if the uterine lining is ready for the embryoimplantation to take place. This occurs around days 19-21 in each menstrual cycle of a fertile woman
This is a crucial step for pregnancy.  No matter how good embryo is, if the test is negative, it will not result in pregnancy. Thus, it helps in finding the cause in repeated ART failures. By changing the dates of the test, one may be able to find a different time frame when the uterus will be receptive to the embryo. This helps in changing the embryo transfer date.
The other solution is to opt for surrogacy, so that one’s own biological child can be grown in another person’s uterus for the 9 months.
The method for the test is quite simple and is done in an outpatient setting by collecting a small sample of the endometrium and sending it for analysis. It is cost effective as it will avoid unnecessary repetition of IVF.

Endometrial receptivity assay ERA – success story 

She came to me for donor egg surrogacy , at 37 yrs ,  she had 5 failed IVF cycles , history of PCOD and teratozoospermia (husband) . After a scientific analysis, we felt she needed to have hysterolaparoscopy, which was surprisingly never suggested . Flimsy tubal adhesions were released and ovarian drilling was done. We also performed endometrial receptivity test ( ERA ). The test was positive and she was very much reassured by the fact that she can conceive.

While they were waiting for an IVF with donor egg next cycle , I suggested IUI. To our great surprise she conceived, had a smooth pregnancy and Caesarian at term. The mother’s joy knew no bounds when she held her beautiful  baby girl. All it took was scratching the uterus !! Psychology may also play an important role, which we ignore most of the time ….

Dr. Anita Mani
Infertility& Surrogacy Specialist at Gift IVF Centre
#4, 3R Plaza HAL 2nd Stage,
100 Feet Road,Indiranagar,
 Bangalore India- 560008

Contact:    +91-8050888880

Near Cochin International Airport Jn.
Athani, Ernakulam Dt, Kerala, India-683585

Contact:    +91-974 5494804

Email:     [email protected]
Web site:

Leave a Reply

Your email address will not be published. Required fields are marked *